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Ubiquitin-K11 human

品牌
Sigma-Aldrich
货号
SRP6129
规格纯度
recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
参考价格
1827.92 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Ubiquitin-K11 human
产品介绍:

产品说明

一般描述

Ubiquitin is a small polypeptide that can be conjugated via its C-terminus to amine groups of lysine residue on target proteins. This conjunction is referred to as monoubiquitylation. Additional ubiquitin moieties can be subsequently conjugated to this initial ubiquitin, utilizing any one of the seven lysine residues on the surface of ubiquitin. The formation of these ubiquitin chains is referred to as polyubiquitylation. This tag-free recombinant form of human ubiquitin is engineered to have all available lysines mutated to arginines, except at position 11. This molecule, therefore, can only form polyubiquitin chains of K11 linkage type. Covalent attachment of ubiquitin to other proteins serves various functions, but its major role is to target cellular proteins for destruction. Cellular components that activate, transfer, remove, or simply recognize ubiquitin number in the hundreds, perhaps even in the thousands. In light of this complexity the ubiquitin pathway is ideal for a systems biology approach. Ubiquitin plays a very important role in regulated non-lysosomal ATP dependent protein degradation. The Ub-proteasome proteolytic pathway, which is a complex process, is implicated to be of great importance for regulating numerous cellular processes.

外形

4 mg/mL in PBS.

制备说明

Centrifuge the vial prior to opening.

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in E. coli
测定≥95% (SDS-PAGE)
形式liquid
分子量 8.732 kDa
包装pkg of 500 μg
NCBI登记号P62979
运输dry ice
储存温度−70℃
Gene Informationhuman ... RPS27A(6233)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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