产品说明
一般描述
ACCN3 (ASIC3) belongs to the degenerin/epithelial sodium channel (DEG/ENaC) protein family. It is known to function as an acid sensor, as well as a sensor of acidic and inflammatory pain. It is also known to enhance H+ gated currents in neurons. ASIC3 has been implicated in ischemic pain and hyperalgesia.
Rabbit Anti-ACCN3 antibody recognizes human, mouse, rat, bovine, and canine ACCN3.
免疫原
Synthetic peptide directed towards the N terminal region of human ACCN3
应用
Rabbit Anti-ACCN3 antibody is suitable for western blot (2.5 μg/ml) and IHC (4-8 μg/ml) applications.
生化/生理作用
ACCN3 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. ACCN3 encodes a member that is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and ACCN1 has been observed as proton-gated channels sensitive to gadolinium.
序列
Synthetic peptide located within the following region: VATFLYQVAERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRL
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | IgG fraction of antiserum |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 58 kDa |
| species reactivity | human |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| NCBI登记号 | NP_004760 |
| UniProt登记号 | Q9UHC3 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... ACCN3(9311) |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
