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GST A2-2, Recombinant Human

品牌
Sigma-Aldrich
货号
GS61
包装型号
规格纯度
参考价格
5525.7 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
GST A2-2, Recombinant Human
GST2
GTH2
GTA2
glutathione S-transferase alpha 2
产品介绍:

产品说明

生化/生理作用

The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual′s susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.
Glutathione S-transferase alpha 2 (GSTA2) is an enzyme that in humans is encoded by the GSTA2 gene. Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The GSTs are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.

储存及稳定性

The enzyme should be used by the end-user customer within 1 year of receipt.

基本信息

NACRESNA.26

产品性质

质量水平100
生物来源human
重组expressed in E. coli
测定>95% (SDS-PAGE)
形式frozen liquid
specific activity15.95 units/mg protein (using spectrophotometric determination of 1-chloro-2,4-dinitrobenzene (CDNB) conjugation with reduced glutathione (1 mM) in 100 mM NaPO4 (pH 6.5) at 30℃.)
分子量 23 kDa
浓度1.52 mg/mL
储存温度−70℃
Gene Informationhuman ... GSTA2(2939)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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