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InSolution IKK-2 Inhibitor IV-Calbiochem

品牌
Sigma-Aldrich
货号
401484
规格纯度
The InSolution IKK-2 Inhibitor IV controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
参考价格
1903.37 *本价格含增值税费
促销
服务
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  • 增值税票
数量
-+
产品名称:
InSolution IKK-2 Inhibitor IV-Calbiochem
产品介绍:

产品说明

一般描述

IKK-2 Inhibitor IV (Cat. No. 401481) supplied in DMSO. A cell-permeable and potent inhibitor of IKK-2 (IC50 = 18 nM) that exhibits selectivity over IKK-1, JNK, and p38 MAPK. Inhibits TNF-α production in human monocytes (IC50 in the range of 0.15-2.5 µM) and blocks IL-8 and IL-6 production by synovial fibroblasts (IC50 = 100 nM). Shown to reduce paw oedema in rat arthritis model (~100% inhibition at a dose of 30 mg/kg).

包装

500 μg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Product competes with ATP.
Reversible: yes

警告

Toxicity: Irritant (B)

外形

A 10 mM (500 µg/179 µl) solution of IKK-2 Inhibitor IV (Cat. No. 401481) in DMSO.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C12H10FN3O2S
分子量279.29

产品性质

质量水平100
测定≥95% (HPLC)
形式liquid
效能18 nM IC50
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated (hygroscopic)
protect from light
颜色clear pale yellow
运输wet ice
储存温度2-8℃

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 2
闪点(F)188.6 °F - (Dimethylsulfoxide)
闪点(C)87 ℃ - (Dimethylsulfoxide)

Sigma-Aldrich

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