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位置:首页 > 品牌 > Sigma-Aldrich > Anti-phospho-p38 (Thr180/Tyr182) Antibody, clone 6E5.2

Anti-phospho-p38 (Thr180/Tyr182) Antibody, clone 6E5.2

品牌
Sigma-Aldrich
货号
MABS64
规格纯度
clone 6E5.2, from mouse
参考价格
5016.79 *本价格含增值税费
促销
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数量
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产品名称:
Anti-phospho-p38 (Thr180/Tyr182) Antibody, clone 6E5.2
mitogen-activated protein kinase 14, cytokine suppressive anti-inflammatory drug binding protein, stress-activated protein kinase 2A, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, MAP kinase MXI2, MAX-interacting pro
产品介绍:

产品说明

一般描述

The p38 family refers to the SAPK2/3 Kinases (Stess-Activated Protein Kinases), a subfamily of JNK/SAPK family. p38/SAPK Kinases are also activated by stresses, most notably inflammatory cytokines, irradiation, and certain toxins such as anisomycin and arsenite. SAPKs have been implicated in many pathological conditions, including inflammation, cancer and neurodegenerative diseases. As with the other MAPK family members (ERK, JNK, p38MAPK, and ERK5), p38 is activated through phosphorylation on both threonine and tyrosine residues at the Thr-X-Tyr dual phosphorylation motif, where X is Gly for p38. Once phosphorylated and active, it then goes on to phosphorylate downstream targets in both the cytoplasm and the nucleus. Some of their main targets of p38 are the kinase MAPKAPK2 and the transcription factor ATF2 that are activated via their phosphorylation.

特异性

This antibody recognizes p38 when phosphorylated at Thr180 and Tyr182.

免疫原

Epitope: Phosphorylated Thr180 and Tyr182
Linear peptide corresponding to human p38 phosphorylated at Thr180 and Tyr182.

应用

Research Sub Category
MAP Kinases
Immunocytochemistry Analysis: 1:500 dilution from a previous lot detected p38 in Anisomycin treated NIH/3T3 cells.
Research Category
Signaling
Detect phospho-p38 (Thr180/Tyr182) using this Anti-phospho-p38 (Thr180/Tyr182) Antibody, clone 6E5.2 validated for use in WB & IC.

质量

Evaluated by Western Blot in Anisomycin treated and untreated HeLa cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected p38 on 10 µg of Anisomycin treated and untreated HeLa cell lysate.

目标描述

41 kDa observed

外形

Purified mouse monoclonal IgGκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Anisomycin treated and untreated HeLa cell lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160702
NACRESNA.41

产品性质

质量水平100
生物来源mouse
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆6E5.2, monoclonal
species reactivitymouse, human
technique(s)immunocytochemistry: suitable
western blot: suitable
NCBI登记号NP_001306.1
UniProt登记号Q16539
运输wet ice
Gene Informationhuman ... MAPK14(1432)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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