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Akt Inhibitor VI, Akt-in-Calbiochem

品牌
Sigma-Aldrich
货号
124013
规格纯度
The Akt Inhibitor VI, Akt-in controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
参考价格
3124.36 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Akt Inhibitor VI, Akt-in-Calbiochem
TCL110-24, H-AVTDHPDRLWAWEKF-OH
产品介绍:

产品说明

一般描述

A reversible 15-mer peptide derived from the amino acids 10-24 of the proto-oncogene TCL1 (TCL10-24) and acts as a specific inhibitor of Akt. Shown to bind to the Akt-PH domain (Kd ~18 µM) and interfere with the Akt-phosphoinositide interaction. This peptide, when made cell-permeable (Cat. No. 124014), has been shown to hinder Akt membrane translocation from the cytosol and subsequent downstream biological responses.
A reversible 15-mer peptide derived from proto-oncogene TCL1 (amino acids 10-24) that acts as a specific inhibitor of Akt. Shown to bind to Akt-PH domain (Kd ~18 µM) and interfere with the Akt-phosphoinositide interaction, thus hindering membrane translocation from the cytosol and downstream biological responses.

包装

2 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Product does not compete with ATP.
Primary Target
Akt
Reversible: yes
Kd ~18 µM in binding to Akt-PH domain
Cell permeable: no

警告

Toxicity: Carcinogenic / Teratogenic (D)

序列

H-Ala-Val-Thr-Asp-His-Pro-Asp-Arg-Leu-Trp-Ala-Trp-Glu-Lys-Phe-OH

外形

Supplied as an acetate salt.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Hiromura, M., et al. 2004. J. Biol. Chem.279, 53407.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C88H123N23O23
分子量1871.06

产品性质

质量水平100
测定≥95% (HPLC)
形式lyophilized solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated (hygroscopic)
颜色 white
溶解性water: 1 mg/mL
运输ambient
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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