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位置:首页 > 品牌 > Sigma-Aldrich > ALDH2 Agonist, Alda-1-CAS 349438-38-6-Calbiochem

ALDH2 Agonist, Alda-1-CAS 349438-38-6-Calbiochem

品牌
Sigma-Aldrich
CAS
349438-38-6
货号
126920
规格纯度
The ALDH2 Agonist, Alda-1, also referenced under CAS 349438-38-6, controls the biological activity of ALDH2. This small molecule/inhibitor is primarily used for Activators/Inducers applications.
参考价格
1762.11 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
349438-38-6
ALDH2 Agonist, Alda-1-CAS 349438-38-6-Calbiochem
N-(1,3-Benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide
产品介绍:

产品说明

一般描述

A cell-permeable benzamide compound that selectively enhances the activity of both the wild-type ALDH2*1 and the east asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (2.1-, 2.2, and 11-fold activation of 20 µg wt homo, wt/mut hetero, and mut homo tetramer, respectively, at 100 µM), while exhibiting no effect toward alcohol dehydrogenase 1, cytosolic ALDH1, or mitochondrial ALDH5. Both PKCε activatior- and ethanol-mediated protections against heart tissue ischemic damage are reported to correlate well with ALDH2 activation, and Alda-1, likewise, is shown to protect against ischemic tissue damage to excised rat hearts (26% and 24% reduction in infarct size and CPK release, respectively; 20 µM) ex vivo and anesthetized live rats (60% infarction reduction; 8.5 mg/kg) in vivo.

包装

25 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following, reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Chen, C.H., et al. 2008. Science321, 1493.

法律信息

Patent pending.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C15H11Cl2NO3
分子量324.16
MDL编号MFCD02055160

产品性质

质量水平100
测定≥95% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 off-white
溶解性ethanol: 10 mg/mL
DMSO: 100 mg/mL
运输ambient
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3

Sigma-Aldrich

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