Anti-MIP-1β antibody produced in chicken

产品说明

一般描述

MIP-1β (macrophage inflammatory protein 1β) is a member of the CC chemokine (cysteine-cysteine) family, and is produced by monocytes and macrophages. This protein exists as a homodimer. It acts as a ligand to the GPCR (G-protein coupled receptor) called CCR5 (CC chemokine receptor 5).

免疫原

Recombinant chemokine C-C motif ligand 4 isoform 1
Immunogen Sequence: GI # 4506845, sequence 27-92

应用

Anti-MIP-1β antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

生化/生理作用

Chemokine (C-C motif) ligand 4 (CCL4) is a principal regulator of macrophage migration and signals through CCR5. CCR5 is linked to several protein kinases including the src kinase Lyn, PI3K, focal adhesion related kinase Pyk2 and members of the MAPK family that help in regulating macrophage chemotaxis. CCL4 is released at the site of inflammation in sarcoidosis.

外形

Solution in phosphate buffered saline containing 0.02% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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