Anti-MUC1 antibody produced in chicken

产品说明

一般描述

Mucin 1 (MUC1) is a O-glycosylated, membrane bound, transmembrane glycoprotein belonging to the mucin (MUC) gene family. It is expressed on the apical surface of mucosal epithelia in the lung, eye, breast and stomach. It consists of an N-terminal extracellular domain consisting of variable number tandem repeats (MUC1-TR) of 20 amino acids (aa) and a C-terminal domain which includes a 53aa extracellular region, a transmembrane domain (TM) and a 72aa cytoplasmic tail (MUC1CT).

免疫原

Immunogen Sequence: GI # 65301117, sequence 199-244
Recombinant MUC1 mucin isoform 1

应用

Anti-MUC1 antibody produced in chicken is suitbale for immunohistochemistry and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

生化/生理作用

Mucin 1, cell surface associated (MUC1), plays an important role in the cell signaling during cancer progression. It carries tumor-associated epitopes and is aberrantly expressed in tumors. MUC1 plays a crucial role in the development, progression of breast cancer and could promote the invasion ability of breast cancer cells. Mutation in the gene may result in progressive chronic kidney failure with a bland urinary sediment.

外形

Solution in phosphate buffered saline containing 0.02% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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