P-Glycoprotein Inhibitor, C-4-Calbiochem

品牌

Sigma-Aldrich

货号

517301

包装型号

10 MG, The P-Glycoprotein Inhibitor, C-4 controls the biological activity of P-Glycoprotein. This small molecule/inhibitor is primarily used for Cancer applications.

规格纯度

The P-Glycoprotein Inhibitor, C-4 controls the biological activity of P-Glycoprotein. This small molecule/inhibitor is primarily used for Cancer applications.

参考价格

2544.41 元 *本价格含增值税费

促销

数量

产品名称：

P-Glycoprotein Inhibitor, C-4-Calbiochem
(E)-4-Chloro-N-(3-(3-(4-hydroxy-3-methoxyphenyl)acryloyl)phenyl)benzamide, C-4

产品介绍：

产品说明

一般描述

A cell-permeable cinnamoyl compound that reversibly inhibits P-gp (P-glycoprotein) efflux function and reverses the MDR (multidrug resistance) phenotype with no noticeable effect on P-gp expression. Shown to significantly enhance Paclitaxel- (Cat. No. 580555) and Vincristine- (Cat. No. 677181) induced cytotoxicity as well as apoptosis in P-gp expressing KBV20C cells.

包装

10 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
P-Glycoprotein
Product does not compete with ATP.
Reversible: yes

警告

Toxicity: Standard Handling (A)

其他说明

Kim, Y.K., et al. 2007. Biochem. Biophys. Res. Commun.355, 136.
Woo, H.B., et al. 2005. Bioorg. Med. Chem. Lett.15, 3782.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₂₃H₁₈ClNO₄
分子量	407.85

产品性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze protect from light
颜色	yellow
溶解性	DMSO: 10 mg/mL
运输	ambient
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 2
闪点(F)	Not applicable
闪点(C)	Not applicable