RAGE Antagonist Peptide, RAP-Calbiochem

产品说明

一般描述

An S100P-derived peptide based competitive antagonist for receptor for advanced glycation end product (RAGE). Shown to disrupt the interaction between RAGE and its ligands, such as S100P, S100A4 and HMGB-1 in binding assays and in multiple cancer cell lines (~2 µM). Also, blocks RAGE-dependent NF-kB activation in MPanc96, MOH and HPAF II tumor cell lines. Systemic administration of RAP also diminishes NF-kB signaling in vivo and significantly reduces glioma tumor growth in murine models.

包装

10 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Primary Target
RAGE
Reversible: yes

警告

Toxicity: Standard Handling (A)

序列

Ac-ELKVLMEKEL-NH2

外形

Supplied as a trifluoroacetate salt.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Arumugam, T., et al. 2012. Clin Cancer Res.18, 4356.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

产品性质

安全信息