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Syk Inhibitor III-CAS 1485-00-3-Calbiochem

品牌
Sigma-Aldrich
CAS
1485-00-3
货号
574713
规格纯度
The Syk Inhibitor III, also referenced under CAS 1485-00-3, controls the biological activity of Syk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
参考价格
2165.23 *本价格含增值税费
促销
服务
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数量
-+
产品名称:
1485-00-3
Syk Inhibitor III-CAS 1485-00-3-Calbiochem
3,4-Methylenedioxy-β-nitrostyrene
产品介绍:

产品说明

一般描述

A cell-permeable nitrostyrene compound that acts as a selective inhibitor of Syk kinase activity (IC50 = 2.5 µM). It inhibits Src only at much higher concentrations (IC50 = 29.3 µM) and exhibits little effect against Fak and JAK2. Shown to potently inhibit platelet aggregation induced by various stimulators, including U46619, ADP, arachidonic acid, collagen, thrombin, ionophore A23187, and PDBu (IC50 ranges from 2.1 to 25.9 µM).

包装

50 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
Syk
Target IC50: 2.5 µM against Syk kinase activity
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Wang, W.Y., et al. 2006. Mol. Pharmacol.70, 1380.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C9H7NO4
分子量193.16
MDL编号MFCD00014575

产品性质

质量水平100
测定≥98% (GC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 yellow to brown
溶解性DMSO: 25 mg/mL (Use only fresh DMSO.)
运输ambient
储存温度−20℃
InChI1S/C9H7NO4/c11-10(12)4-3-7-1-2-8-9(5-7)14-6-13-8/h1-5H,6H2/b4-3-
InChI keyKFLWBZPSJQPRDD-ARJAWSKDSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H315 - H319
预防措施声明P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
危险分类Eye Irrit. 2 - Skin Irrit. 2
储存分类代码11 - Combustible Solids
WGKWGK 3

Sigma-Aldrich

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