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TRAIL, Human, Recombinant, NSO cells

品牌
Sigma-Aldrich
货号
616376
包装型号
规格纯度
参考价格
7913.37 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
TRAIL, Human, Recombinant, NSO cells
Apo2L; TNF-Related Apoptosis-Inducing Ligand
产品介绍:

产品说明

一般描述

Recombinant, human TRAIL expressed in NSO cells a type II transmembrane protein with a C-terminal extracellular domain, which exhibits homology to other TNF family members. Displays potent antitumor activity against selected targets. Induces apoptosis in a number of transformed cell lines but not in normal tissues.
Recombinant, human TRAIL (amino acids 95-281) with an amino-terminal 6X histidine tag and expressed in NSO cells. A type II transmembrane protein with a C-terminal extracellular domain that exhibits homology to other members of this tumor necrosis factor (TNF) family. Displays potent anti-tumor activity against selected targets. Induces apoptosis in a number of transformed cell lines but not in normal tissues. Recombinant bioactive TRAIL is a non-disulfide-linked homotrimer but may contain a small amount (up to 10%) of disulfide-linked homodimers.

包装

10 μg in Plastic ampoule

生化/生理作用

ED₅₀ = 4-12 ng/ml as measured by its ability to induce cytotoxicity in mouse L-929 cell line in the presence of metabolic inhibitors actinomycin D

警告

Toxicity: Standard Handling (A)

外形

Lyophilized from sterile-filtered PBS, 50 µg BSA/µg TRAIL, pH 7.4.

重悬

Reconstitute to ≥20 µg/ml in sterile PBS, 0.1% BSA.
Following reconstitution, refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C or -70°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or up to 3 months at -20°C or -70°C. Avoid freeze/thaw cycles of solutions.

其他说明

Griffith, T.S., et al. 1999. J. Exp. Med.189, 1343.
Mariani, S.M., et al. 1997. J. Cell Biol.137, 221.
Pan, G., et al. 1997. Science277, 815.
Pan, G., et al. 1997. Science276, 111.
Sheridan, J.P., et al. 1997. Science277, 818.
Pitti, R.M., et al. 1996. J. Biol. Chem.271, 12687.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

产品性质

质量水平100
重组expressed in NSO cells
测定≥97% (SDS-PAGE)
形式lyophilized
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
杂质≤1 EU/μg Endotoxin (EU/μg TRAIL)
运输ambient
储存温度−70℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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