Anti-APBA1 antibody produced in rabbit

产品说明

一般描述

APBA1 (Amyloid β (A4) precursor protein binding, family A, member 1) is a neuronal adaptor protein belonging to the X11 family. It consists of a centrally located phosphotyrosine binding domain, which inhibits the production of Aβ peptide, two C-terminal postsynaptic density-95, large discs, zona occludens 1 (PDZ) domains.

免疫原

Synthetic peptide directed towards the N terminal region of human APBA1

应用

Anti- APBA1 antibody produced in rabbit is suitable for western blotting at a concentration of 0.25 μg/ml. For immunohistochemistry of paraffin-embedded tissue sections, a concentration of 4-8 μg/ml is suitable.

生化/生理作用

APBA1 (Amyloid β (A4) precursor protein binding, family A, member 1) stabilizes amyloid precursor protein (APP) by directly interacting with it. It also restricts production as well as accumulation of proteolytic APP fragment in the brain of Alzheimer′s disease patients. It also suppresses glycogen synthase kinase-3β promoter activity by coupling with a silencer binding protein.

序列

Synthetic peptide located within the following region: PPQQQHYVGRHQRGRALEDLRAQLGQEEEERGECLARSASTESGFHNHTD

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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