产品说明
一般描述
This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. (provided by RefSeq)
免疫原
CER1 (AAH69491.1, 1 a.a. ~ 267 a.a) full-length human protein.
Sequence
MHLLLFQLLVLLPLGKTTRHQDGRQNQSSLSPVLLPRNQRELPTGNHEEAEEKPDLFVAVPHLVGTSPAGEGQRQREKMLSRFGRFWKKPEREMHPSRDSDSEPFPPGTQSLIQPIDGMKMEKSPLREEAKKFWHHFMFRKTPASQGVILPIKSHEVHWETCRTVPFSQTITHEGCEKVVVQNNLCFGKCGSVHFPGAAQHSHTSCSHCLPAKFTTMHLPLNCTELSSVIKVVMLVEECQCKVKTEHEDGHILHAGSQDSFIPGVSA
应用
Anti-CER1 antibody produced in mouse is suitable for western blot assay.
生化/生理作用
Cerberus 1 (CER1) is associated with the regulation of various pathways including nodal, Wnt, or BMP signaling pathways. During bone development, it acts as an inhibitor of BMPs (bone morphogenetic proteins). Polymorphisms in CER1 has link with osteoporosis, on bone mineral density (BMD) and bone markers in osteoporotic women. It has been reported that CER1 has been identified as a potential marker for bone mineral density and bone markers in osteoporotic women.
外形
Solution in phosphate buffered saline, pH 7.4
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
NACRES | NA.41 |
产品性质
质量水平 | 100 |
生物来源 | mouse |
偶联物 | unconjugated |
抗体形式 | purified immunoglobulin |
antibody product type | primary antibodies |
克隆 | polyclonal |
形式 | buffered aqueous solution |
分子量 | antigen ~30.1 kDa |
species reactivity | human |
technique(s) | western blot: 1 μg/mL |
NCBI登记号 | BC069491 |
UniProt登记号 | O95813 |
运输 | dry ice |
储存温度 | −20℃ |
Gene Information | human ... CER1(9350) |
安全信息
储存分类代码 | 13 - Non Combustible Solids |
WGK | WGK 1 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich