Anti-DFFA antibody produced in rabbit

产品说明

一般描述

DFFA (DNA fragmentation factor, α polypeptide) is a heterodimeric 45kDa protein mapped on chromosome location 1p36.2-36.3. It is localized to the chromatin fraction under both the conditions, apoptotic and non-apoptotic state. Its expression also has been found in neuroblastoma (NB) cell lines.

免疫原

Synthetic peptide directed towards the N terminal region of human DFFA

应用

Anti-DFFA antibody produced in rabbit is suitable for western blot analysis.

生化/生理作用

DFFA (DNA fragmentation factor, α polypeptide) functions as a chaperone of DNA fragmentation factor 40 (DFF40) in apoptosis and balancing genomic stability. The activity of DFF is induced by cleavage of DFFA by caspase-3, resulting in release of DFF40, which degrades chromosomal DNA. During menstruation, the apoptosis of endometrium cells is associated with DFFA activation. DFFA expression decreases after menopause. DFFA is a target of miR-145.

序列

Synthetic peptide located within the following region: MEVTGDAGVPESGEIRTLKPCLLRRNYSREQHGVAASCLEDLRSKACDIL

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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