产品说明
一般描述
The gene Ectodysplasin A receptor (EDAR) is mapped to human chromosome 2q11-q13. It is a transmembrane member of tumor necrosis factor receptor family.
免疫原
Synthetic peptide directed towards the middle region of human EDAR
应用
Anti-EDAR antibody produced in rabbit is suitable for western blotting at a concentration of 1.0μg/ml.
生化/生理作用
Ectodysplasin A receptor (EDAR) binds ectodysplasin A (EDA) and uses EDARADD (Ectodysplasin-A receptor-associated adapter protein) as an adapter protein. It activates critical signaling pathways involving NF-κB (Nuclear factor κ B) and JNK (c-Jun N-terminal kinase). The activity of EDAR is essential during the development of eccrine sweat glands, hair and teeth. Mutations in EDAR gene result in hypohidrotic ectodermal dysplasia.
序列
Synthetic peptide located within the following region: PAPDKQGSPELCLLSLVHLAREKSATSNKSAGIQSRRKKILDVYANVCGV
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 48 kDa |
| species reactivity | bovine, mouse, horse, human, rat, dog |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | western blot: suitable |
| NCBI登记号 | NP_071731 |
| UniProt登记号 | Q9UNE0 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... EDAR(10913) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
