Anti-FICD antibody produced in rabbit

产品说明

免疫原

Synthetic peptide directed towards the C terminal region of human FICD

应用

Anti-FICD antibody produced in rabbit is suitable for western blotting at a concentration of 0.25μg/mL. It is also useful for immunohistochemistry at a concentration of 4-8μg/mL.

生化/生理作用

FICD (FIC domain-containing protein) is a 458 amino acid containing single pass membrane protein. FICD facilitates the addition of adenosine 5′-monophosphate (AMP) to specific residues of target proteins. Hence, it mediates the AMP addition to RhoA, Rac and Cdc42 and inactivates the Rho GTPases in vitro. Additionally, FICD arbitrates bacterial pathogenesis as well as eukaryotic posttranslational modification, which may facilitate in regulating key signaling events. In mammalian cells, Fic proteins injected by pathogenic bacteria stimulate the adenylylation of small GTPases that results in collapse of the actin cytoskeleton and cell death.

序列

Synthetic peptide located within the following region: GDVRPFIRFIAKCTETTLDTLLFATTEYSVALPEAQPNHSGFKETLPVKP

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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