产品说明
一般描述
The members of Smad protein family mediate the signal transduction of TGF-β. Signaling via Smad/TGF-β have been implicated in development, homeostasis and cancer development.
免疫原
Synthetic peptide directed towards the N terminal region of human SMAD6
应用
Anti-SMAD6 (AB1) antibody produced in rabbit is suitable for western blotting at a concentration of 1 μg/ml.
生化/生理作用
Smad6 is an inhibitory Smad member that antagonizes the effects of TGF-β and BMP signaling. The mechanism of inhibition involves competing with receptor-regulated Smads. Smad6 inhibits the non-canonical pathway of TGF-β, regulating the activation of p38 MAPK/JNK.
序列
Synthetic peptide located within the following region: GAPRDASDPLAGAALEPAGGGRSREARSRLLLLEQELKTVTYSLLKRLKE
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 53 kDa |
| species reactivity | human |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | western blot: suitable |
| NCBI登记号 | NP_001136333 |
| UniProt登记号 | O43541 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... SMAD6(4091) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
