产品说明
一般描述
TFCP2 is a transcription factor that forms a part of the human (gamma)-globin gene. This transcription factor is known to regulate erythroid gene expression and has been implicated in Alzheimer′s disease.
Rabbit Anti-TFCP2 antibody recognizes chicken, human, mouse, rat, canine, and bovine TFCP2.
免疫原
Synthetic peptide directed towards the N terminal region of human TFCP2
应用
Rabbit Anti-TFCP2 antibody can be used for western blot (1μg/ml) assays.
生化/生理作用
TFCP2 binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1. It also functions as part of the SSP (stage selector protein) complex. TFCP2 facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. It interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter.
序列
Synthetic peptide located within the following region: YSMSDVLALPIFKQEESSLPPDNENKILPFQYVLCAATSPAVKLHDETLT
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | 57 kDa |
| species reactivity | dog, rabbit, bovine, human, mouse, pig, horse |
| 浓度 | 0.5 mg - 1 mg/mL |
| technique(s) | western blot: suitable |
| NCBI登记号 | NP_005644 |
| UniProt登记号 | Q12800 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... TFCP2(7024) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
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