Anti-THEX1 antibody produced in rabbit

产品说明

一般描述

Three prime histone mRNA exonuclease 1/exoribonuclease 1 (THEX1, ERI1,) is a 3′ exonuclease that binds to the 3′ end of mammalian histone mRNAs and degrades them. The rapid degradation of histone mRNA by ERI1 occurs upon completion and/or inhibition of DNA replication. ERI1 may also negatively regulate RNA interference via degradation of siRNA.

特异性

Anti-THEX1 polyclonal antibody reacts with human, mouse, rat, canine, chicken, zebrafish, and bovine three prime histone mRNA exonuclease 1 proteins.

免疫原

Synthetic peptide directed towards the C terminal region of human THEX1

应用

Anti-THEX1 polyclonal antibody is used to tag three prime histone mRNA exonuclease 1 for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of three prime histone mRNA exonuclease 1 in histone mRNA degradation during phases of DNA replication.

生化/生理作用

THEX1 contains 1 SAP domain and 1 exonuclease domain. It is an RNA exonuclease that binds to the 3′ end of histone mRNAs and probably degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. It is also able to degrade the 3′ overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi).

序列

Synthetic peptide located within the following region: GSWDMSKFLNIQCQLSRLKYPPFAKKWINIRKSYGNFYKVPRSQTKLTIM

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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