LY 303511-CAS 154447-38-8-Calbiochem

产品名称：

154447-38-8
LY 303511-CAS 154447-38-8-Calbiochem
2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor V, BRD3 Inhibitor IV, BRD4 Inhibitor V

产品介绍：

产品说明

一般描述

A cell-permeable, negative control for the phosphatidylinositol-3-kinase (PI-3 kinase) inhibitor, LY 294002 (Cat. No. 440202). Contains a single atom substitution in the morpholine ring compared to LY 294002. Does not affect PI-3 kinase activity even at concentrations ≥100 µM.
A cell-permeable negative control for the PI 3-kinase inhibitor LY 294002 (Cat. No. 440202). Contains a single atom substitution in the morpholine ring compared to LY 294002. Does not inhibit PI 3-kinase even at a concentration of 100 µM. Shown to bind to the same site as I-BET (Cat. no. 401010) and reversibly inhibit BET bromodomain proteins BRD2, BRD3 & BRD4 (IC₅₀ ~10 µM).

包装

1 mg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Target IC₅₀: Does not inhibit PI 3-kinase even at a concentration of 100 µM
Product does not compete with ATP.
Reversible: no
Primary Target
Negative control for the PI 3-kinase inhibitor LY 294002

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

其他说明

Dittman, et al. 2014. ACS Chem Biol.9, 495.
Ding, J., et al. 1995. J. Biol. Chem.270, 11684.
Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₁₉H₁₈N₂O₂
分子量	306.36

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem^®
储存条件	OK to freeze
颜色	amber
溶解性	DMSO: 100 mg/mL
运输	ambient
储存温度	−20℃
InChI	1S/C19H18N2O2/c22-17-13-18(21-11-9-20-10-12-21)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13,20H,9-12H2
InChI key	NGAGMBNBKCDCDJ-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1