Cathepsin L Inhibitor IV-Calbiochem

产品说明

一般描述

A potent, cell-permeable, selective, and reversible inhibitor of cathepsin L (IC₅₀ = 1.9 nM). Inhibits the release of Ca²⁺ and hydroxyproline from bone in a bone culture system and prevents bone loss in ovariectomized mice (~50 mg/kg).
A potent, cell-permeable, selective, and reversible inhibitor of cathepsin L (IC₅₀ = 1.9 nM). Also inhibits the release of Ca²⁺ and hydroxyproline from bone in an in vitro bone culture system and prevents bone loss in ovariectomized mice (~50 mg/kg).

包装

1 mg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Target IC₅₀: 1.9 nM against Cathepsin L
Product does not compete with ATP.
Primary Target
cathepsin L
Reversible: yes

警告

Toxicity: Standard Handling (A)

序列

1-Naphthalenesulfonyl-Ile-Trp-CHO

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Yasuma, T., et al. 1998. J. Med. Chem. 41, 4301.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

产品性质

安全信息