Indirubin-3'-monoxime-5-sulphonic Acid-CAS 331467-05-1-Calbiochem

产品说明

一般描述

A potent, reversible, and selective inhibitor of Cdk1 (IC₅₀ = 5 nM) and Cdk5 (IC₅₀ = 7 nM) and glycogen synthase kinase-3β (GSK-3β; IC₅₀ = 80 nM). The inhibition is competitive with respect to ATP.
A highly potent, reversible, and selective inhibitor of cyclin-dependent kinases 1 and 5 (IC₅₀ = 5 nM for CDK1; IC₅₀ = 7 nM for CDK5). Reported to act by competing with ATP for binding to the catalytic site of the kinase. Also acts as a potent inhibitor of glycogen synthase kinase-3β (GSK-3β; IC₅₀ = 80 nM).

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
CDK1
Product competes with ATP.
Target IC₅₀: 5 nM, 7 nM, 80 nM, against Cdk1, Cdk5, and glycogen synthase kinase-3β (GSK-3β), respectively
Cell permeable: no
Reversible: yes

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 4 months at -20°C.

其他说明

Leclerc, S., et al. 2001. J. Biol. Chem.276, 251.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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