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Raf1 Kinase Inhibitor I-CAS 220904-83-6-Calbiochem

品牌
Sigma-Aldrich
CAS
220904-83-6
货号
553008
规格纯度
The Raf1 Kinase Inhibitor I, also referenced under CAS 220904-83-6, controls the biological activity of Raf1 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
参考价格
2340.22 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
220904-83-6
Raf1 Kinase Inhibitor I-CAS 220904-83-6-Calbiochem
5-Iodo-3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-2-indolinone, GW 5074
产品介绍:

产品说明

一般描述

A potent, cell-permeable, reversible, and ATP-competitive cRAF1 kinase inhibitor (IC50 = 9 nM). Shows ≥100-fold selectivity for Raf kinase versus Cdk1, Cdk2, c-Src, ERK2, MEK, p38, Tie2, VEGFR2, and c-Fms. Predicted broad spectrum antitumor agents. A 10 mM (500 µg/96 µl) solution of Raf1 Inhibitor I (Cat. No. 553003) in DMSO is also available.
A potent, cell-permeable, reversible, and ATP-competitive cRaf1 kinase inhibitor (IC50 = 9 nM). Shows ≥100-fold selectivity for Raf kinase versus Cdk1, Cdk2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fms. cRaf1 inhibitors are predicted to be broad spectrum antitumor agents.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
CRAFI kinase
Product competes with ATP.
Reversible: yes

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.







From Catalog:

Desc. Field- added "Predicted broad spectrum antitumor agents."

其他说明

Lackey, K., et al. 2000. Bioorg. Med. Chem. Lett.10, 223.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C15H8Br2INO2
分子量520.94
MDL编号MFCD03453076

产品性质

质量水平100
测定≥97% (HPLC)
形式solid
效能9 nM IC50
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色dark orange
溶解性DMSO: 200 mg/mL
运输ambient
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3

Sigma-Aldrich

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