Anthrax Lethal Factor Protease Inhibitor, In-2-LF-Calbiochem

产品说明

一般描述

A cell-permeable derivative of a 14-mer peptide that is based on the MEK-2 template and acts as a competitive inhibitor of Anthrax lethal factor metalloprotease (K_i = 1 nM). Also inhibits MEK-3 cleavage. Exhibits protective effects against Anthrax toxin-induced cytotoxicity in RAW264.7 and J772.A1 cells. Reported to competitively inhibit furin (K_i = 49 nM.
A cell-permeable N-acetylated, C-hydroxamate derivative of a 14-mer peptide designed from the MEK-2 template that acts as a competitive inhibitor of Anthrax lethal factor (LF) metalloprotease (K_i = 1 nM). Also inhibits MEK-3 cleavage. Protects against Anthrax toxin induced cytotoxicity in RAW264.7 and J772.A1 cells.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
anthrax LF metalloprotease
Product does not compete with ATP.
Cell permeable: yes
Target K_i: 1 nM against Anthrax lethal factor (LF) metalloprotease
Reversible: no

警告

Toxicity: Standard Handling (A)

序列

Ac-Gly-Tyr-βAla-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Val-Leu-Arg-NHOH

外形

Supplied as a trifluoroacetate salt.

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Peinado, J.R., et al. 2004. Biochem. Biophys. Res. Commun.321, 601.
Tonello, F., et. al. 2002. Nature418, 386.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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