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PARP Inhibitor IX, EB-47-Calbiochem

品牌
Sigma-Aldrich
货号
324473
规格纯度
The PARP Inhibitor IX, EB-47 controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.
参考价格
2096.01 *本价格含增值税费
促销
服务
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数量
-+
产品名称:
PARP Inhibitor IX, EB-47-Calbiochem
产品介绍:

产品说明

一般描述

A cell-permeable, adenosine-substituted, isoindolinone compound that acts as a potent inhibitor of PARP-1 (IC50 = 45 nM). Shown to offer cytoprotective effects against oxidative damage in cells and in in vivo models of reperfusion injury and inflammation.
A cell-permeable, adenosine-substituted, isoindolinone compound that acts as a potent inhibitor of poly (ADP-ribose) polymerase-1 (PARP-1) (IC50 = 45 nM). Reported to offer cytoprotective effects against oxidative damage in cells and in in vivo models of reperfusion injury and inflammation.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
PARP-1

警告

Toxicity: Carcinogenic / Teratogenic (D)

重悬

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Jagtap, P.G., et al. 2004. Bioorg. Med. Chem. Lett.14, 81.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C24H27N9O6 · 2HCl · 2H2O
分子量646.48

产品性质

质量水平100
测定≥95% (HPLC)
形式solid
效能45 nM IC50
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated (hygroscopic)
protect from light
颜色 white
溶解性water: 50 mg/mL
运输wet ice
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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