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Anti-FLIPγ/δ, C-Terminal antibody produced in rabbit

Anti-FLIPγ/δ, C-Terminal antibody produced in rabbit

品牌
Sigma-Aldrich
货号
F9925
规格纯度
1 mg/mL, affinity isolated antibody, buffered aqueous solution
参考价格
5427.59 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-FLIPγ/δ, C-Terminal antibody produced in rabbit
Anti-CLARP
Anti-CASH
Anti-FLAME-1
Anti-I-FLICE
产品介绍:

产品说明

一般描述

In human Viral FLICE-inhibitory proteins (v-FLIPs) is identified as c-FLIP. It is composed of two death effector domains which have structural resemblance with the N-terminal half of caspase-8 and a caspase-like domain. It exist as multiple splice variants: FLIP α, β, γ and δ. Along with splice variants, it has two endogenous forms of the protein − c-FLIPlong and c-FLIPshort.

免疫原

FLIP antibody was raised against a 19 amino acid peptide near the carboxy terminus of human FLIP.
The immunogen is located within amino acids 180 - 230 of FLIP.

应用

Anti-FLIPγ/δ, C-Terminal antibody is suitable for microarray and western blot at a dilution of 1:1,000 using HeLa, Jurkat, THP-1, A431, K562, and NIH-3T3 cell lysates.

生化/生理作用

C-FLIP plays an important role in apoptosis signaling pathways. It acts as proapoptotic molecule or as an anti-apoptotic molecule. It has been reported that c-FLIP can interact with both FADD and caspase-8. It prevents caspase-8 recruitment and processing through DED-DED (Death Effector Domain) interaction followed by CD95-induced apoptosis.

外形

Solution in 0.01 M phosphate buffered saline containing 0.02% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD02096351
NACRESNA.41

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen 25 kDa (FLIPδ/FLIPS)
antigen 35 kDa (FLIPγ)
species reactivityhuman, mouse
浓度1 mg/mL
technique(s)immunocytochemistry: 2 μg/mL
immunofluorescence: 10 μg/mL
western blot: 1:1,000
UniProt登记号O15519
储存温度−20℃
Gene Informationhuman ... CFLAR(8837)
mouse ... Cflar(12633)

Sigma-Aldrich

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