产品说明

一般描述

The antibody will neutralize the biological activity of recombinant mouse IL-4, but not recombinant human IL-4. It shows <5% cross-reactivity with recombinant rat IL-4, and shows no cross-reactivity with recombinant human IL-4.

免疫原

recombinant mouse IL-4.

生化/生理作用

Interleukin-4 (IL-4) is a T cell derived chemokine that stimulates the Th2 mediated immune response and proliferation of B cells. The effects of IL-4 are mediated by two types of receptors, type I receptor consisting of IL-4Rα and common γ chain and type II receptor composed of IL-4Rα and IL-13Rα1. The signaling stimulated by IL-4 leads to activation of JAK/STAT6 and IRS-mediated PI3K/Akt pathway. IL-4 is responsible for endocytic activity of macrophages, chemotaxis of leukocytes in response to inflammation, angiogenesis and regulation of nitric oxide metabolism in macrophages.

外形

Lyophilized from 0.2 μm filtered solution in phosphate buffered saline..

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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