Anti-phospho-Insulin Receptor/Insulin-Like Growth Factor-1 Receptor (pTyr¹¹⁵⁸/^1162/1163) antibody produced in rabbit

产品说明

一般描述

Insulin-like growth factors -1 and -2 are important regulators of signalling that mediates growth and metabolism in cells. Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades. IGF 1R is fully activated by phosphorylation of tyrosine residues at Tyr¹¹⁵⁸, Tyr¹¹⁶² and Tyr¹¹⁶³. The effect of IGF-1 is by endocrine, paracrine and autocrine signalling. The effects of IGF-1R signalling are important at many developmental levels from cells to organ to organism, growth, differentiation, anti-apoptosis, proliferation and transformation. Irregular IGF-1 signaling has been implicated in many cancers including melanoma, breast, lung, colon and prostate
Anti-phospho-IR/IGF1R (pTyr¹¹⁵⁸/¹¹⁶²/¹¹⁶³) specifically recognizes human receptor and insulin-like growth factor-1 receptor phosphorylated at tyrosines 1158, 1162 and 1163. It may cross react with mouse and rat IR/IGF1R (100% homology).

免疫原

synthetic phosphopeptide derived from the region of IR that contains tyrosines 1158, 1162, and 1163.

应用

Anti-phospho-IR/IGF1R (pTyr¹¹⁵⁸/¹¹⁶²/¹¹⁶³) antibody may be used for immunoblotting at a working concentration of 0.1-1.0 μg/ml using whole cell lysates from CHO-T cells.

外形

Solution in Dulbecco′s phosphate buffered saline, pH 7.3, containing 50% glycerol, 1 mg/mL BSA (IgG and protease-free) and 0.05% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

产品性质

安全信息