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Caspase-3/7 Inhibitor I-CAS 220509-74-0-Calbiochem

品牌
Sigma-Aldrich
CAS
220509-74-0
货号
218826
规格纯度
The Caspase-3/7 Inhibitor I, also referenced under CAS 220509-74-0, controls the biological activity of Caspase-3/7. This small molecule/inhibitor is primarily used for Cancer applications.
参考价格
2096.01 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
220509-74-0
Caspase-3/7 Inhibitor I-CAS 220509-74-0-Calbiochem
5-[(S)-(+)-2-(Methoxymethyl)pyrrolidino]sulfonylisatin
产品介绍:

产品说明

一般描述

A potent, reversible, isatin sulfonamide-based inhibitor of caspase-3 (KI(app) = 60 nM) and caspase-7 (KI(app) = 170 nM). Inhibits caspase-9 to a lesser extent (Ki(app) = 3.1 µM). Has only a trivial effect (Ki(app) >25 mM) on the activities of caspase-1, caspase-2, caspase-4, caspase-6, and caspase-8. Reported to inhibit apoptosis in camptothecin treated Jurkat cells (IC50 ~50 µM). Also reported to inhibit apoptosis in chondrocytes (44% inhibition at 10 µM and 98% inhibition at 50 µM). Selectivity for caspases 3 and 7 involves unique hydrophobic residues in the S2 pocket surrounding the catalytic cysteine residue.
A potent, cell-permeable, and specific, reversible inhibitor of caspase-3 (Ki = 60 nM) and caspase-7 (Ki = 170 nM).

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
caspase-3
Product does not compete with ATP.
Reversible: yes
Cell permeable: yes
Target Ki: 60 nM, 170 nM, against caspase-3 and caspase-7, respectively

警告

Toxicity: Standard Handling (A)

序列

5-[(S)-(+)-2-(Methoxymethyl)pyrrolidino]sulfonylisatin

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Lee, D., et al. 2001. J. Med. Chem.44, 2015.
Lee, D., et al. 2000. J. Biol. Chem. 275, 16007.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C14H16N2O5S
分子量324.35

产品性质

质量水平100
测定≥98% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 yellow
溶解性methanol: 10 mg/mL
DMSO: 200 mg/mL
运输ambient
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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