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Anti-Activin Receptor IIB antibody produced in goat

品牌
Sigma-Aldrich
货号
A0457
规格纯度
affinity isolated antibody
参考价格
4731.57 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
Anti-Activin Receptor IIB antibody produced in goat
ActRIIB
产品介绍:

产品说明

一般描述

Anti-Activin Receptor IIB recognizes recombinant human activin receptor IIB by methods such as immunoblotting and ELISA. The antibody can inhibit receptor-ligand interaction. In ELISA assays, the antibody can block 50% of the binding of recombinant human activin A to recombinant human activin receptor IIB/Fc chimera. Furthermore, the antibody exhibits 15% cross-reactivity with recombinant human activin receptor I. This antibody shows no cross reactivity with recombinant human activin receptor IA, IIA, and IB using ELISA and immunoblotting methods.
Activin is a disulfide-linked dimeric protein released by grandulosa cells in the ovary and sertoli cells in the testis. Activin Receptor IIB belongs to Ser/Thr protein kinase family and can transduce the activin signal from the cell surface to the cytoplasm. Activin will not bind directly to Type I activin receptors rather it will associate with the type II receptor-activin complex and start signal transduction. Many ligands signal through Activin Receptor IIB can regulate muscle growth. Anti-Activin Receptor IIB antibody can be used in flow cytometry and immunohistochemistry. Goat Anti- Activin Receptor IIB antibody reacts specifically with recombinant human activin receptor IIB. The product has shown no cross-reactivity for human activin receptor IA, recombinant human activin receptor IIA or recombinant human activin receptor IB.

免疫原

purified, NSO-derived, recombinant human activin receptor IIB extracellular domain.

应用

Goat anti-activin receptor IIB antibody can be used for immunohistochemistry (5 μg/mL) and flow cytometry (10 μL) applications.
Anti-Activin Receptor IIB can be used in western blotting (working concentration-0.1-0.2 μg/mL) for detecting human activin receptor IIB.

外形

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5% trehalose

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD01864596
NACRESNA.41

产品性质

质量水平200
生物来源goat
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
species reactivityhuman
technique(s)flow cytometry: 10 μL using 1-2.5 x 105 cells (of a 25 μg/mL dilution)
immunohistochemistry: 5 μg/mL
western blot: 0.1-0.2 μg/mL
UniProt登记号Q13705
储存温度−20℃
Gene Informationhuman ... ACVR2B(93)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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