产品说明
一般描述
Retinoblastoma (Rb) is a pediatric intraocular neoplasm caused due to the biallelic inactivation of the RB1 gene. Retinoblastoma is also known as RB1 (RB transcriptional corepressor 1). It is located on human chromosome 13q14. It is a tumor suppressor gene.
免疫原
synthetic phosphopeptide derived from the region of human Rb that contains Ser811.
生化/生理作用
Retinoblastoma (RB) interacts with several protein factors to control the expression of target genes which promote cell cycle arrest, apoptosis, and differentiation. It helps to modulate nucleosome and chromatin structures. Absence of RB induces prostate cancer metastasis.
外形
Solution in Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, with 1.0 mg/mL BSA (IgG and protease free) and 0.05% sodium azide.
基本信息
| MDL编号 | MFCD06411917 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 200 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| species reactivity | human, mouse, rat |
| technique(s) | western blot: 0.5-1.5 μg/mL using Jurkat cells in high growth phase. |
| UniProt登记号 | P06400 |
| 运输 | dry ice |
| 储存温度 | −70℃ |
| Gene Information | human ... RB1(5925) mouse ... Rb1(19645) rat ... Rb1(24708) |
Sigma-Aldrich
m.cnreagent.com
