产品说明
一般描述
The extracellular domain (160 amino acids) of mouse CD152 is fused to mouse IgG2a Fc domain in which mutations to the complement (C1q) and FcγR I binding sites of the Fcγ2a fragment render the Fc fusion protein incapable of direct antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).
生化/生理作用
CD152 (CTLA4), a cell surface glycoprotein expressed at low levels on activated T cells, is a high affinity receptor for the costimulatory molecules CD80 (B7-1) and CD86 (B7-2). A related cell surface glycoprotein, CD28, binds to CD80 and CD86 with lower affinity. The soluble CD152/Fc chimeric fusion protein blocks the B7/CD28 signaling pathway by binding to CD80 and CD86.
外形
Lyophilized from solution of 0.2 μm filtered, in phosphate buffered saline, pH 7.4, with no preservative added.
制备说明
Purified from serum-free tissue culture supernatant
基本信息
| MDL编号 | MFCD01092888 |
| NACRES | NA.32 |
产品性质
| 质量水平 | 200 |
| 重组 | expressed in NS.1 cells |
| 测定 | ≥98% (SDS-PAGE) |
| 形式 | lyophilized |
| 分子量 | 97 kDa |
| UniProt登记号 | P09793 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | mouse ... Ctla4(12477) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
Sigma-Aldrich
m.cnreagent.com
