产品说明
Amino Acid Sequence
Z-Leu-Leu-Nva
包装
1, 5 mg in serum bottle
生化/生理作用
Potent inhibitor of the 20S proteasome (Ki = 21 nM) and 26S proteasome (Ki = 35 nM). Cells treated with 54 μM N-CBZ-Leu-Leu-Norvalinal showed complete block of the G1/S and metaphase transitions and delayed passage through S-phase. Induces apoptosis in Rat-1 and PC12 cells, perhaps by accumulation of stabilized p53.
基本信息
| 经验(实验)分子式 | C25H39N3O5 |
| 分子量 | 461.59 |
| PubChem化学物质编号 | 329775129 |
| NACRES | NA.32 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥90% (HPLC) |
| 形式 | powder |
| 颜色 | white |
| 溶解性 | DMSO: soluble |
| 储存温度 | −20℃ |
| SMILES string | CCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C=O |
| InChI | 1S/C25H39N3O5/c1-6-10-20(15-29)26-23(30)21(13-17(2)3)27-24(31)22(14-18(4)5)28-25(32)33-16-19-11-8-7-9-12-19/h7-9,11-12,15,17-18,20-22H,6,10,13-14,16H2,1-5H3,(H,26,30)(H,27,31)(H,28,32)/t20-,21-,22-/m0/s1 |
| InChI key | QEJRGURBLQWEOU-FKBYEOEOSA-N |
| Gene Information | human ... PSMA1(5682), PSMC1(5700) mouse ... PSMA1(26440), PSMC1(19179) rat ... PSMA1(29668), PSMC1(117263) |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
Sigma-Aldrich
m.cnreagent.com
