Tubulin Polymerization Inhibitor II

产品说明

一般描述

A cell-permeable, SU5416- (Cat. Nos. 676487 and 676498) derived combretastatin A-4 (Cat. No. 234200) analog that acts as an effective anti-microtubule agent (IC₅₀ = 4.5 µM in inhibiting polymerization of purified porcine brain tubulin) and displays extremely potent anti-proliferative activity towards various cancer cell lines (GI₅₀<10 nM for 46 lines among a 53 NCI panel tested).

包装

5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Target IC₅₀: 4.5 µM in inhibiting polymerization of purified porcine brain tubulin
Product does not compete with ATP.
Reversible: no
Primary Target
Purified porcine brain tubulin

警告

Toxicity: Harmful (C)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Pandit, B., et al. 2006. Bioorg. Med. Chem.14, 6492.
Li, P.K., et al. 2005. Bioorg. Med. Chem. Lett.15, 5382.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

产品性质

安全信息