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位置:首页 > 品牌 > Sigma-Aldrich > PI 3-Kδ Inhibitor X, IC87114-CAS 371242-69-2-Calbiochem

PI 3-Kδ Inhibitor X, IC87114-CAS 371242-69-2-Calbiochem

品牌
Sigma-Aldrich
CAS
371242-69-2
货号
528118
规格纯度
The PI 3-Kδ Inhibitor X, IC87114, also referenced under CAS 371242-69-2, controls the biological activity of PI 3-Kδ. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
参考价格
1954.93 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
371242-69-2
PI 3-Kδ Inhibitor X, IC87114-CAS 371242-69-2-Calbiochem
Phosphatidylinositol 3-Kinase p110d Inhibitor, PI 3-K Inhibitor X
产品介绍:

产品说明

一般描述

A cell permeable, selective inhibitor of PI 3-Kδ (IC50= 1.82, 0.07, and 1.24 for p110b, p110d, and p110g, respectively, but may also target p110a at concentrations as high as 100 µM with less potency) in NB-4 and primary APL cells. It has been reported that the constitutive activation of PI3K/Akt signaling in primary AML cells is predominantly attributable to PI 3-Kδ. Pharmacologic use of PI 3-Kδ inhibitor has been shown to block PI3K/Akt/mTOR signaling and could thereby reduce proliferation and induce apoptosis. A related study further suggests PI 3-Kδ inhibitor as a key therapeutic target among PI 3-K isoforms for allergy- and mast cell-related diseases.
A cell permeable, selective inhibitor of PI 3-Kδ (IC50= 1.82, 0.07, and 1.24 for p110b, p110d, and p110g, respectively, but may also target p110a at concentrations as high as 100 µM with less potency) in NB-4 and primary APL cells. It has been reported that the constitutive activation of PI3K/Akt signaling in primary AML cells is predominantly attributable to PI 3-Kδ. Pharmacologic use of PI 3-Kδ inhibitor has been shown to block PI3K/Akt/mTOR signaling and could thereby reduce proliferation and induce apoptosis. A related study further suggests PI 3-Kδ inhibitor as a key therapeutic target among PI 3-K isoforms for allergy- and mast cell-related diseases.

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Billottet, C., et al. 2009. Cancer Res.69,1027.
Ali, K., et al. 2008. J. Immunol.180, 2538.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C22H19N7O
分子量397.43

产品性质

质量水平100
测定≥95% (HPLC)
形式powder
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
颜色 white
溶解性DMSO: 5 mg/mL
运输wet ice
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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