产品说明
一般描述
A cell-permeable dipeptide aldehyde that acts as a specific, potent, slow and tight-binding transition state analog inhibitor of prolyl endopeptidase (Ki = 350 pM and 500 pM for mouse brain and human brain prolyl endopeptidase, respectively). Reported to form a hemiacetal with the active-site serine.
A cell-permeable dipeptide aldehyde that acts as a specific, potent, slow, and tight-binding transition state analog inhibitor of prolyl endopeptidase (Ki = 350 pM and 500 pM for mouse brain and human brain, respectively). Reported to form a hemiacetal with the active site serine of the enzyme.
包装
5 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Product does not compete with ATP.
Target Ki: 350 pM and 500 pM for mouse brain and human brain prolyl endopeptidase, respectively
Cell permeable: yes
Primary Target
Mouse brain prolylendooeotidase
Reversible: no
警告
Toxicity: Standard Handling (A)
序列
Z-Pro-Pro-CHO
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Fülöp, V., et al. 1998. Cell94, 161.
Kahyaoglu, A., et al. 1997. Biochem. J.322, 839.
Bakker, A.V., et al. 1990. Biochem. J.271, 559.
Wilk, S., and Orlowski, M. 1983. J. Neurochem.41, 69.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
经验(实验)分子式 | C18H22N2O4 |
分子量 | 330.38 |
产品性质
质量水平 | 100 |
测定 | ≥97% (HPLC) |
形式 | oil |
manufacturer/tradename | Calbiochem® |
储存条件 | OK to freeze protect from light |
颜色 | colorless to off-white |
溶解性 | DMSO: 10 mg/mL DMF: soluble ethyl acetate: soluble |
运输 | ambient |
储存温度 | −20℃ |
安全信息
储存分类代码 | 10 - Combustible liquids |
WGK | WGK 1 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich