4-Cyano-3-methylisoquinoline

产品说明

一般描述

A potent, cell-permeable, specific inhibitor of protein kinase A (PKA; IC₅₀ = 30 nM). Inhibition is competitive with respect to ATP. Shows only weak inhibitory activities against Ca²⁺-dependent protein kinase (CDPK), MLCK, PKC, and cyclic nucleotide-binding phosphatase (Pase).
A potent, cell-permeable, reversible, and specific inhibitor of protein kinase A (IC₅₀ = 30 nM). Inhibition is competitive with respect to ATP. Shows only weak inhibitory activities against Ca²⁺-dependent protein kinase (CDPK), MLCK, PKC, and cyclic nucleotide-binding phosphatase.

包装

5 mg in Glass bottle
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Target IC₅₀: 30 nM against protein kinase A
Product competes with ATP.
Reversible: yes
Primary Target
PKA

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Lu, Z.X., et al. 1996. Biol. Chem. Hoppe Seyler 377, 373.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

产品性质

安全信息