(R)-N4-Hydroxy-N1-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide

产品名称：

142880-36-2
(R)-N4-Hydroxy-N1-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide
Galardin
GM6001
Ilomastat

产品介绍：

产品说明

应用

(R)-N4-Hydroxy-N1-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide has been used:

To study its effect on the profiling of active aggrecanases and their specific aggrecan degradation fragments.
To study the involvement of autocrine EGF (epidermal growth factor) receptor activation in the regulation of the morphogenetic process, using human umbilical vein endothelial cells.
To study the effect of GM6001 blockade on the expression of angiotensin II, the interstitial collagenases and soluble elastin fragments in explant culture supernatants.

生化/生理作用

GM6001 promotes cardiovascular and hepatocellular function.
Inhibits a wide variety of matrix metalloproteases with K_is in the nanomolar range. Active in a number of animal models of diseases where matrix metalloproteases are thought to be involved.

基本信息

经验(实验)分子式	C₂₀H₂₈N₄O₄
分子量	388.46
PubChem化学物质编号	329818026
NACRES	NA.77

产品性质

质量水平	200
测定	>95% (HPLC)
形式	solid
储存温度	2-8℃
SMILES string	CNC([C@@H](NC([C@@H](C(C)C)CC(NC)=O)=O)CC1=CNC2=CC=CC=C21)=O
InChI	1S/C20H28N4O3/c1-12(2)15(10-18(25)21-3)19(26)24-17(20(27)22-4)9-13-11-23-16-8-6-5-7-14(13)16/h5-8,11-12,15,17,23H,9-10H2,1-4H3,(H,21,25)(H,22,27)(H,24,26)/t15-,17+/m1/s1
InChI key	PFBWZAGFLVKAGR-WBVHZDCISA-N

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, type N95 (US)