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FABP4 Inhibitor-CAS 300657-03-8-Calbiochem

品牌
Sigma-Aldrich
CAS
300657-03-8
货号
341310
规格纯度
The FABP4 Inhibitor, also referenced under CAS 300657-03-8, controls the biological activity of FABP4.
参考价格
2785.91 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
300657-03-8
FABP4 Inhibitor-CAS 300657-03-8-Calbiochem
adipocyte Fatty-Acid-Binding Protein Inhibitor, ((2'-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)(1,1'-biphenyl)-3-yl)oxy)-acetic acid, BMS309403, BMS-309403, BMS 309403
产品介绍:

产品说明

一般描述

A cell-permeable biphenylazolo-oxyacetate that acts as a potent and selective inhibitor of adipocyte Fatty-Acid-Binding Protein (aFABP/aP2) by targeting its fatty acid-binding pocket (Ki = <2 nM in a competitive binding assay using 1,8-ANS), while exhibiting much lower affinity for muscle and epidermal FABP′s (Ki = 250 nM and 350 nM, respectively). Shown to effectively block foam cell transformation and the cellular expression of inflammatory mediators in aP2-positive, but not aP2-negative, THP-1 macrophage in vitro, as well as improve the glucose metabolism and insulin sensitivity in mice in vivo.

包装

5 mg in Plastic ampoule
Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Furuhashi, M., et al. 2007. Nature447, 959.
Sulsky, R., et al. 2007. Bioorg. Med. Chem. Lett.17, 3511.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C31H26N2O3
分子量474.55
MDL编号MFCD09991687

产品性质

质量水平200
测定≥98% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 white
溶解性ethanol: 20 mg/mL
DMSO: 50 mg/mL
methanol: 50 mg/mL
运输ambient
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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