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Enantioprobe (S,S)-7

品牌
Sigma-Aldrich
CAS
2390040-83-0
货号
912182
规格纯度
≥95%
参考价格
1104.53 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
2390040-83-0
Enantioprobe (S,S)-7
Ligandability probe
Fully functionalized enantioprobe
N-((1S,2S)-2-(Benzyloxy)cyclopentyl)-3-(3-(but-3-yn-1-yl)-3H-diazirin-3-yl)propanamide
产品介绍:

产品说明

应用

Enantioprobe (S,S)-7 is one of 16 fully functionalized, enantiomeric fragment probes developed in the Cravatt lab. Combining fragment-based ligand discovery (FBLD) with chemical proteomics, the enantioprobe library assesses ligandability across proteomes. Each enantioprobe contains a structurally variable fragment for interaction with proteins, photoactivatable diazirine for UV-induced covalent protein labeling, and bioorthogonal alkyne handle for detection, enrichment, and identification. Of the eight enantiomeric pairs, each differs by one stereocenter, and comparing stereoselective fragment-protein interactions betweenthe pairs simplifies validation of authentic protein-binding events. Enantioprobe (S,S)-7′s paired fragment is available as Enantioprobe (R,R)-7 (cat# 913413).

Together, the 16 enantioprobes support ligandability studies in living cells, a significant method for development of chemical probes and lead discovery efforts to find binders for traditionally ″″undruggable″″ protein targets. This strategy is also compatible with multiplexing for higher throughput.
Supporting reagents:

  • Fluorophore-conjugated azide tags for SDS-PAGE in-gel profiling: 910147, 760757, 760765, 777315, 777323
  • Azide-biotin tags for enrichment: 901765, 914134, 914460, 762024, 900912, 900891, QBD10825
  • Azide capture solid supports: 900957, 742627
  • Streptavidin for biotin enrichment: S6940, E5529, E2513, 69203, 16-126, S1638
  • Mass spectrometry and Multiplexing

其他说明

Technology Spotlight: Proteomic Ligandability Assessment

Expedited mapping of the ligandable proteome using fully functionalized enantiomeric probe pairs

A chiral trick to map protein ligandability

基本信息

经验(实验)分子式C20H25N3O2
分子量339.43

产品性质

质量水平100
测定≥95%
形式powder
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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