2OHOA

产品名称：

56472-29-8
2OHOA
(9Z)-2-Hydroxy-9-octadecenoic acid; cis-2-Hydroxy-9-octadecenoic acid
2-Hydroxy Oleic Acid
Minerval

产品介绍：

产品说明

应用

2OHOA has been used as:

a modulator of the sphingolipid and glycerophospholipid pathway to study its effects on myelination in mice Charcot–Marie–Tooth type 1A (CMT1A) myelinopathy and myelinating dorsal root ganglia cultures
in biophysical studies to study its effects on artificial membranes
to study its interactions with major membrane lipid films

包装

5, 25 mg in glass bottle

生化/生理作用

2-Hydroxy oleic acid (2OHOA) is a derivative of oleic acid. It plays a role in membrane organization, alterations in membrane fluidity, an increase of the tendency to form non-lamellar structures, and remodeling of microdomains by interacting with the lipids in membranes of pathological cells.
2OHOA induces cell cycle arrest and apoptosis in several cancer cell lines, including glioma, leukemia, breast and colon cancer lines. 2OHOA increases sphingomyelin (SM) levels in the membranes of tumor cells, which typically display decreased SM membrane content, and remodeled membranes, compared with normal cells. The compound has no effect on SM levels in non-cancer cells.

基本信息

经验(实验)分子式	C₁₈H₃₄O₃
分子量	298.46
MDL编号	MFCD07778553
PubChem化学物质编号	329825264
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
储存条件	protect from light
颜色	white to tan
溶解性	DMSO: >20 mg/mL
储存温度	room temp
SMILES string	CCCCCCCC\C=C/CCCCCCC(O)C(O)=O
InChI	1S/C18H34O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(19)18(20)21/h9-10,17,19H,2-8,11-16H2,1H3,(H,20,21)/b10-9-
InChI key	JBSOOFITVPOOSY-KTKRTIGZSA-N

安全信息

象形图
警示用语：	Danger
危险声明	H318
预防措施声明	P280 - P305 + P351 + P338
危险分类	Eye Dam. 1
储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable