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2OHOA

品牌
Sigma-Aldrich
CAS
56472-29-8
货号
SML0256
规格纯度
≥98% (HPLC)
参考价格
1272.2 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
-+
产品名称:
56472-29-8
2OHOA
(9Z)-2-Hydroxy-9-octadecenoic acid; cis-2-Hydroxy-9-octadecenoic acid
2-Hydroxy Oleic Acid
Minerval
产品介绍:

产品说明

应用

2OHOA has been used as:

  • a modulator of the sphingolipid and glycerophospholipid pathway to study its effects on myelination in mice Charcot–Marie–Tooth type 1A (CMT1A) myelinopathy and myelinating dorsal root ganglia cultures
  • in biophysical studies to study its effects on artificial membranes
  • to study its interactions with major membrane lipid films

包装

5, 25 mg in glass bottle

生化/生理作用

2-Hydroxy oleic acid (2OHOA) is a derivative of oleic acid. It plays a role in membrane organization, alterations in membrane fluidity, an increase of the tendency to form non-lamellar structures, and remodeling of microdomains by interacting with the lipids in membranes of pathological cells.
2OHOA induces cell cycle arrest and apoptosis in several cancer cell lines, including glioma, leukemia, breast and colon cancer lines. 2OHOA increases sphingomyelin (SM) levels in the membranes of tumor cells, which typically display decreased SM membrane content, and remodeled membranes, compared with normal cells. The compound has no effect on SM levels in non-cancer cells.

基本信息

经验(实验)分子式C18H34O3
分子量298.46
MDL编号MFCD07778553
PubChem化学物质编号329825264
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
储存条件protect from light
颜色 white to tan
溶解性DMSO: >20 mg/mL
储存温度room temp
SMILES stringCCCCCCCC\C=C/CCCCCCC(O)C(O)=O
InChI1S/C18H34O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(19)18(20)21/h9-10,17,19H,2-8,11-16H2,1H3,(H,20,21)/b10-9-
InChI keyJBSOOFITVPOOSY-KTKRTIGZSA-N

安全信息

象形图GHS05
警示用语:Danger
危险声明H318
预防措施声明P280 - P305 + P351 + P338
危险分类Eye Dam. 1
储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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