AP39

产品名称：

1429061-80-2
AP39
(10-Oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)decyl)triphenylphosphonium bromide
AP 39
AP-39

产品介绍：

产品说明

生化/生理作用

AP39 is a anethole dithiolethione (ADT-OH)-derivatized hydrogen sulfide (H2S) donor with a lipophilic & positively charged triphenylphosphonium (TP) moiety for mitochondrially targeted H2S release. AP39 stimulates mitochondrial electron transport and cellular bioenergetic function, protecting against mitochondrial DNA damage and cell death upon oxidative stress induction (effective conc. 30–100 nM; bEnd.3 cells). AP39 in vivo efficacy (0.1-1 μmol/kg i.v.; 0.1-0.3 mg/kg i.p.) is demonstrated in varous rodent models, including neurological damage post cardiac arrest, renal injury post ischemia-reperfusion, burn-caused organ damage, as well as brain atrophy in APP/PS1 mice.

基本信息

经验(实验)分子式	C₃₇H₃₈BrO₂PS₃
分子量	721.77

产品性质

测定	≥95% (HPLC)
形式	powder
颜色	white to dark orange
溶解性	DMSO: 2 mg/mL, clear
运输	wet ice
储存温度	−20℃
SMILES string	O=C(OC1=CC=C(C2=CC(SS2)=S)C=C1)CCCCCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5.[Br-]

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable