α-(Fluoromethyl)-D/L-tyrosine

产品名称：

73804-76-9
AFMT racemate
Alpha-(FluoroMethyl)-D/L-Tyrosine
α-(Fluoromethyl)-D/L-tyrosine
(R/S)-2-Amino-3-fluoro-2-(4-hydroxybenzyl)propanoic acid
(R/S)-α-Fluoromethyltyrosine
D/L-AFMT

产品介绍：

产品说明

生化/生理作用

A racemic mixture of D- and L-AFMT. L-AFMT is reported to selectively inhibt against gut bacteria E. faecalis pyridoxal-5′-phosphate (PLP)-dependent tyrosine decarboxylase (TyrDC)-, but not aromatic amino acid decarboxylase (AADC)-, mediated L-dopa decarboxylation (IC50 = 4.7 μM/cell-free, 1.4 μM/in E. faecalis cultures; 20% human AADC inhibition at 650 μM) via covalent adduct formation with TyrDC co-factor PLP. When co-administered with L-dopa (10 mg/kg) and the AADC inhibitor carbidopa (30 mg/kg) to gnotobiotic mice colonized with E. faecalis, L-AFMT (25 mg/kg) significantly increases L-dopa peak serum concentration.

基本信息

经验(实验)分子式	C₁₀H₁₂FNO₃
分子量	213.21

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear (warmed)
储存温度	2-8℃
SMILES string	OC1=CC=C(C=C1)CC(N)(C(O)=O)CF

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable