Bisdemethoxycurcumin

产品名称：

Bisdemethoxycurcumin
(1E,6E)-1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione

产品介绍：

产品说明

应用

Bisdemethoxycurcumin has been used:

to test its inhibitory effect on cell cycle and mitochondrial function in gastric adenocarcinoma cells
to test it neuroprotective role against lead (Pb) induced toxicity in dopaminergic and noradrenergic systems of Meriones shawi
as a standard for calibration curve generation to quantify plasma curcuminoids using high-performance liquid chromatography-diode array detection (HPLC-DAD) and ultraviolet (UV)

包装

5, 25 mg in glass bottle

生化/生理作用

Bisdemethoxycurcumin (BDMC) is a derivative or curcumin, and represents one of the major active components of curcumin products isolated from Curcumae sp. BDMC shares similar anti-inflammatory properties with demethoxycurcumin. It inhibits LPS-induced nitric oxide (NO) production and expression of iNOS and COX2 in RAW264.7 cells by blocking NF-kB activation. BDMC also displays unique properties in that it enhances Abeta clearance by upregulating expression MGAT3 and TLR genes. BDMC potently inhibits AKR1B10.
Bisdemethoxycurcumin (BMDC) is a stable dimethoxy derivative of curcumin and is useful as a supplement in cell culture medium. It also possesses antimicrobial, antioxidative and neuroprotective functionality.

基本信息

经验(实验)分子式	C₁₉H₁₆O₄
分子量	308.33
MDL编号	MFCD03419284
PubChem化学物质编号	329773290
NACRES	NA.77

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	solid
溶解性	DMSO: ≥20 mg/mL
储存温度	2-8℃
SMILES string	Oc1ccc(cc1)\C=C\C(=O)CC(=O)\C=C\c2ccc(O)cc2
InChI	1S/C19H16O4/c20-16-7-1-14(2-8-16)5-11-18(22)13-19(23)12-6-15-3-9-17(21)10-4-15/h1-12,20-21H,13H2/b11-5+,12-6+
InChI key	PREBVFJICNPEKM-YDWXAUTNSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable