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BAY-850 trihydrochloride

品牌
Sigma-Aldrich
CAS
2099142-76-2
货号
SML2748
规格纯度
≥98% (HPLC)
参考价格
2521.28 *本价格含增值税费
促销
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数量
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产品名称:
2099142-76-2
BAY-850 trihydrochloride
N-((R)-1-((1s,4S)-4-Aminocyclohexylamino)-3-(4-cyanophenyl)propan-2-yl)-2-chloro-4-methoxy-5-(5-(((R)-1-p-tolylethylamino)methyl)furan-2-yl)benzamide trihydrochloride
N-[(2R)-1-[(4-Aminocyclohexyl)amino]-3-(4-cyanophenyl)propan-2-yl]-2-chloro-4-methoxy-5-[5-({[(1R)-1-(4-methylphenyl)ethyl]amino}methyl)-2-furyl]benzamide trihydrochloride
产品介绍:

产品说明

生化/生理作用

BAY-850 is a chemical probe that targets ATPase family AAA domain-containing protein 2 (ATAD2) bromodomain (BD) with submicromolar affinity (Kd of 84.9 nM by MST and 120 nM by BROMOscan) and high selectivity over all other bromodomains tested (no BROMOscan hits at 10 μM). BAY-850 blocks ATAD2 BD from binding acetylated H4 peptide in cell-free assays (IC50 of 20 nM) and displaces full-length ATAD2 from chromatin in live cells (effctive conc. 1 μM by HTRF). To avoid potential unspecific off-target effects, concentrations above 5 μM are not recommended. BAY-460 is a companion control compound with strongly reduced ATAD2 inhibitory potency (IC50 = 16 μM by cell-based HTRF assay; no activity at 10 μM by BROMOscan).

基本信息

经验(实验)分子式C38H44ClN5O3 · 3HCl
分子量763.62

产品性质

质量水平100
测定≥98% (HPLC)
形式powder
颜色 white to beige
溶解性H2O: 2 mg/mL, clear
储存温度2-8℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3

Sigma-Aldrich

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