ARL-17477 dihydrochloride hydrate

产品名称：

866914-87-6
ARL-17477 dihydrochloride hydrate
N-[4-[2-[[(3-chlorophenyl)methyl]amino]ethyl]phenyl]-2-thiophenecarboximidamide dihydrochloride hydrate

产品介绍：

产品说明

应用

ARL-17477 dihydrochloride hydrate may be used in cell signaling studies.

包装

5, 25 mg in glass bottle

生化/生理作用

ARL-17477 is an nNOS specific inhibitor. The IC₅₀ against rat nNOS is 35 nM and it has 100-fold selectivity over endothelial and inducible isoforms. ARL-17477 penetrates the brain, and reduces infarct size and reduces cerebral blood flow in several different rodent models of ischemic brain injury.

特点和优势

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

基本信息

经验(实验)分子式	C₂₀H₂₀ClN₃S·2HCl · xH₂O
分子量	442.83 (anhydrous basis)
MDL编号	MFCD21608518
PubChem化学物质编号	329825207

产品性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
储存条件	desiccated
颜色	white to beige
溶解性	H₂O: ≥5 mg/mL
创始人	AstraZeneca
储存温度	2-8℃
SMILES string	O.Cl.Cl.Clc1cccc(CNCCc2ccc(NC(=N)c3cccs3)cc2)c1
InChI	1S/C20H20ClN3S.2ClH.H2O/c21-17-4-1-3-16(13-17)14-23-11-10-15-6-8-18(9-7-15)24-20(22)19-5-2-12-25-19;;;/h1-9,12-13,23H,10-11,14H2,(H2,22,24);2*1H;1H2
InChI key	QOPATWWWZNTSQF-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302 - H319
预防措施声明	P301 + P312 + P330 - P305 + P351 + P338
危险分类	Acute Tox. 4 Oral - Eye Irrit. 2
储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable