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ELND006

品牌
Sigma-Aldrich
CAS
1333990-84-3
货号
SML2122
规格纯度
≥98% (HPLC)
参考价格
1445.69 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
1333990-84-3
ELND006
(R)-4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline
产品介绍:

产品说明

生化/生理作用

ELND006 is an allosteric γ-secretase inhibitor that selectively blocks amyloid-β (Aβ) over Notch production both in cell-free (Aβ IC50/Notch IC50 = 0.34 nM/6.6 nM) and cell-based assays (Aβ IC50/Notch IC50 = 1.3 nM/85 nM). ELND006 is orally available and blood-brain barrier-permeable (total/unbound conc in brain = 0.12 μM/1.0 nM, 0.52 μM/4.5 nM, 2.1 μM/18 nM and total/unbound conc in plasma = 0.031 μM/0.28 nM, 0.19 μM/1.7 nM, 0.90 μM/8.1 nM 3 h post 1, 3, 10 mg/kg oral dosage in rats, respectively), and shown to effectively reduce cortical Aβx-40 in mice in vivo (by 32%, 48%, and 61% 3 h post 1, 3, 10 mg/kg oral dosage).

基本信息

经验(实验)分子式C20H14F5N3O2S
分子量455.40
MDL编号MFCD28386354

产品性质

测定≥98% (HPLC)
形式powder
旋光性[α]/D -125 to -140°, c = 0.5 in ethanol
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear
储存温度2-8℃

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3

Sigma-Aldrich

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