Fexinidazole

产品名称：

Fexinidazole
HOE 239
1-methyl-2-[[4-(methylthio)phenoxy]methyl]-5-nitro-1H-imidazole

产品介绍：

产品说明

生化/生理作用

Anti Trypanosoma, Leishmania agent.
Fexinidazole is a potent anti-Trypanosoma agent. Trypanosoma species human protozoan pathogens are responsible for sleeping sickness and Chagas disease. In vivo, fexinidazole is oxidized to sulfoxide and sulfone metabolites that are effective in blocking the progression of the parasitic disease visceral leishmaniasis. The mechanism of action appears to be by reductive activation via an NADH-dependent nitroreductase expressed by the parasites.

基本信息

经验(实验)分子式	C₁₂H₁₃N₃O₃S
分子量	279.31
MDL编号	MFCD00866607

产品性质

测定	≥98% (HPLC)
形式	powder
颜色	light yellow to dark brown
溶解性	DMSO: 2 mg/mL, clear
储存温度	−20℃
SMILES string	CN1C(COC2=CC=C(SC)C=C2)=NC=C1[N+]([O-])=O

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable